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Cardiovascular risk increases with a higher LDL particle count. With a higher non-HDL count, the probability of particle penetration of the arterial walls rises, regardless of the total amount of cholesterol contained in each particle. More than 30% of the population has cholesterol-depleted LDL, a condition in which a patient’s cholesterol may be “normal” but their lipoprotein particle number, and hence their actual risk, could be much higher than expected. This is especially common in people whose triglycerides are high or HDL is low. In the population with a cholesterol-depleted LDL, there can be up to a 40% error in risk assessment.